Understanding Continuous kIDNEY Replacement Therapy (CKRT) in COVID-19 Treatment & Management


The novel coronavirus (COVID-19) outbreak is evolving quickly, with new developments every day. Considering the potential for ICU patient surge, Dr. Casey Gashti* reviews his expertise regarding what is known about COVID-19 and how hybrid therapies, such as Prolonged Intermittent Kidney Replacement Therapy (PIKRT), may improve resource utilization while treating patients with AKI.


  • Early Clinical Experience with COVID-19 and CKRT
  • Clinical Impact of an ICU Patient Surge
  • Prolonged Intermittent Kidney Replacement Therapy (PIKRT) ; Hybrid KRT Options for AKI
    • Patient Selection
    • PIKRT Prescriptions and Dose Calculation
    • Antibiotic Dosing  Recommendations


Casey Gashti, MD
Associate Professor of Nephrology and Medical Director for Inpatient Plasmapheresis
Rush University Medical Center
Chicago, IL

Casey Gashti, MD, is board certified in Nephrology and Internal Medicine and is affiliated with Rush University Medical Center, Chicago, Illinois. He completed his residency in Internal Medicine and his Fellowship in Nephrology at Rush University Medical Center, where he is currently Associate Professor of Nephrology and the Medical Director for Inpatient Plasmapheresis.

Dr. Gashti is a member of the American College of Physicians (ACP), American Society for Apheresis (AFSA) and the American Society of Nephrology (ASN).

*Paid speaker for NxStage Medical, Inc.

RISK INFORMATION: Renal replacement therapy, as with any medical therapy, is not without risks. The decision of which therapy to use should be made by the physician, based on previous experience and on the individual facts and circumstances of the patient. There is no literature demonstrating one therapy is clinically better than another.1

1. D.M. Nash, S. Przech, R.Wald, and D. O'Reilly, "Systematic review and meta-analysis of renal replacement Therapy modalities for acute kidney injury in the intensive care unit," Journal of Critical Care. vol. 41, pp. 138-144, 2017.



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