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Low serum albumin levels can influence your patients' health

A majority of dialysis patients begin therapy with low serum albumin levels (<4g/dL).2 Low serum albumin is associated with a high risk of adverse health outcomes.3 Choose a dialyzer with an albumin-sparing design.6



Low serum albumin can increase your patients' risk of hospitalization4

Dialyzers that leak albumin may present a problem for patients4

Serum albumin is a beneficial protein and a key indicator of patient health. Once serum albumin levels drop below recommended levels, restoring normal levels is challenging.5 Dialyzers that have the potential to leak albumin during the course of treatment4 may contribute to hypoalbuminemia.

Learn more about how Optiflux® high-flux dialyzers can help your patients

Choose Optiflux: The #1 high-flux dialyzer brand in the US.8 Designed to preserve albumin.6

Optiflux high-flux dialyzers have been shown to clear out harmful toxins while preserving serum albumin.6 After six months of treatment with Optiflux, 87% of patients with hypoalbuminemia observed a mean increase in serum albumin levels.7

Optiflux dialyzers are prescribed by nephrologists more than 600 million times and counting.8

  1. NKF KDOQI Clinical Practice Guidelines. Am J Kidney Dis. 2000. Jun; 35(6 Suppl2}: S1-S140.
  2. United States Renal Data System. 2018 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2018.
  3. Don BR, Kaysen G. 2004. Serum Albumin: Relationship to Inflammation and Nutrition. Seminars in Dialysis 17(6):432-7.
  4. Tsuchida, Kenji et al. Albumin Loss Under the Use of the High-Performance Membrane, Department of Kidney Disease (Artificial Kidney and Kidney Transplantation), Kawashima Hospital, Tokushima City, Tokushima, Japan.
  5. Kayson GA. Serum albumin concentration in dialysis patients: why does it remain resistant to therapy? Kidney Int. 2003;64 (Suppl 87):592-598.
  6. Fresenius Medical Care (2016). Instructions for Use: Optiflux High Flux Ebeam P/N 89-705-44 Rev A 02/2016
  7. Zhou, M., et al. Evaluation of Biomarkers in Chronic Hemodialysis Patients Dialyzed with Optiflux High-Flux Dialyzers, Poster Presentation, NKF Spring Clinical Meetings, 2020. Cause and effect not determined based on design.
  8. FMCNA data on file as of March 2020.

Indications for use: Optiflux F160NRe, F180NRe, F200NRe, and F250NRe dialyzers are intended for patients with acute or chronic renal failure when conservative therapy is judged to be inadequate. The suitability of a dialyzer for a particular treatment is the responsibility of the physician.

Caution: Federal (US) law restricts these devices to sale by or on order of a physician.

Note: Read the Instructions for Use for safe and proper use of these devices. For a complete description of hazards, contraindications, side effects, and precautions, see full package labeling at In rare cases, thrombocytopenia or hypersensitivity reactions including anaphylactic or anaphylactoid reactions to the dialyzer or other elements in the extracorporeal circuit may occur during hemodialysis.

© 2020 Fresenius Medical Care. All Rights Reserved. Fresenius Medical Care, the triangle logo, Fresenius Renal Technologies, Fresenius Polysulfone, and Optiflux are trademarks of Fresenius Medical Care Holdings, Inc. or its affiliated companies. All other trademarks are the property of their respective owners. P/N 104341-01 Rev A 07/2020