Kidney Replacement Therapy (KRT)
Cartridge Express | Express Kit

Clotting or clogging of the circuit is a common occurence associated with kidney replacement therapy.1 As a result, this may cause therapy downtime. The Speedswap cartridge allows you to change a flow-compromised NxStage® filter without replacing the cartridge through the use of a pre-attached — yet durable — filter.

When changing a flow-compromised NxStage filter, Speedswap is designed to decrease:

Therapy Downtime2

Nursing Workload3

Treatment Costs3



Learn More about Speedswap

To learn more about Speedswap, please fill out the form below.


CAR-535: Cartridge Express with Speedswap4

A. Shipping Connectors
Designed to maintain sterility and integrity of valves during storage and the shipping process. 

B. Valves
The valves enable the user to disconnect the pre-attached filter. When disconnected, designed to stop fluid from flowing; when connected, designed to allow fluid to flow.

C. Line Restrictor

Designed to allow for pressure adjustment within the venous and arterial lines. Also allows for connections to alternate sources of access.  

D. Safe2 Rotator Connector
Features a spin-lock designed to prevent accidental disconnect and improved handling for greater flexibility and durability.

E. Pressure Oscillating Diaphragm (POD) Technology

Created to eliminate blood-air interface, which may reduce the risk of clotting and related therapy interruptions.5

F. Needless Valve
Designed for easy, on-demand aspiration or injection of fluids and complies with needle-free policies and legislation.6

SSK-535: Speedswap Express Kit4

A. Replacement Filter
Delivers high clearance of small and middle weight molecules through:

  • Peformance enhancing technology (PET)7,8
  • Uniform pore distribution7,8
  • Sieving enhancing technology (SET)7,8

B. Priming Spike
Designed to connect to a standard bag of saline for Speedswap gravity prime

C. Priming Card

Designed to facilitate the priming of the replacement filter by holding the tubing in the appropriate position

D. Drain Bag
Designed to collect the saline used during the gravity prime process of the replacement filter


Product Information

Explore the product benefits and components.

Learn more about the innovative Speedswap cartridge and how it works.

Product Support

For more information or product support, contact us at 1-866-NxStage (697-8243).

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Risk Information
Kidney replacement therapy, as with any medical therapy, is not without risks. The decision of which therapy to use should be made by the physician, based on previous experience and on the individual facts and circumstances of the patient. There is no literature demonstrating one therapy is clinically better than another.9 NxViewTM is contraindicated as the sole method of monitoring a patient during treatment. The Speedswap cartridge can only be used with the following software versions and user guide:

  • NxView Software 3.0 or higher
  • SystemOneTM Cycler Software 4.14 or higher
  • NxStage SystemOne User Guide NC4921 Rev. J r higher


  1. Joannidis M, Oudemans-van Straaten HM. Clinical Review: Patency of the Circuit in Continuous Renal Replacement Therapy. Crit Care 2007;11(4):218.
  2. NxStage System One Critical Care User Guide. NC4921 Rev. J. 2021.
  3. Data on file, 08/2021.
  4. Instructions for Use CAR-535/SSK-535. NC45-0926. Rev. E. 04/2021.
  5. Polaschegg HD. Mechanical Aspects of Dialysis; The Extracorporeal Circuit. Semin Dial 1005;8(5):299-304.
  6. Needlestick Prevention and Safety Act, 106th Congress, Public Law 106-430, 2000.
  7. Filter Membrane Webinars, part 1, www.nxstage.com. Data on file, February 2010, 3M GmbH. www.membrana.com
  8. Filter Membrane Webinars, part 2, www.nxstage.com. Data on file, May 2010, 3M GmbH. www.membrana.com
  9. D. M. Nash, S Przech, R. Wald, and D. O'Reilly, "Systematic review and meta-analysis of renal replacement therapy modalities for acute kidney injury in the intensive care init," Journal of Critical Care, vol. 41, pp. 138-144, 2017.

Federal law restricts this device to sale by or on the order of a physician.

© 2022 Fresenius Medical Care. All rights Reserved. Fresenius Medical Care, the triangle logo, NxStage, Speedswap, NxView, and System One are trademarks of Fresenius Medical Care Holdings, Inc. or its affiliated companies. All other trademarks are the property of their respective owners. P/N 104988-01 Rev A 04/2022 APM4464 Rev A